![]() According to the results, it was found that ILE treatment is a lifesaving agent in lipophilic drug intoxications and it can be used in unconscious patients who have cardiac and/or neurologic symptoms but no history of a specific drug ingestion.Ĭopyright © 2014 Elsevier Inc. SMOFlipid at the same dose as the IntraLipid and advance to 3 g/kg/. Intravenous dosage (20 soybean oil-based lipid emulsions i.e., Intralipid, Nutrilipid): Adults: 1.5 mL/kg (lean body weight) IV bolus administered over 1 to. ![]() In our case series, ILE was used for different lipophilic drug intoxications to improve cardiovascular and neurologic symptoms. If switching from IntraLipid at dose higher than 1 g/kg/day, change from IntraLipid to. ![]() Complications were observed in 2 patients (minimal change pancreatitis and probable ILE treatment-related fat infiltration in lungs). In 34/46 (73) cases an intravenous bolus of 1.5ml/kg of a 20 solution of intralipid followed by 0.25-0.5 ml/kg/min constant rate infusion for 30-60 minutes was administered. Intravenous lipid emulsion treatment improved Glasgow Coma Scale or blood pressure and pulse rate or both according to the drug type. The exact dose and rate of ILE administered was recorded in 46 dogs (87). Our case series involved 10 patients with ingestion of different types of lipophilic drugs. Not only does ILE have demonstrable efficacy as an antidote to local anesthetic toxicity, it is also effective in lipophilic drug intoxications. Intravenous lipid emulsion (ILE) is a lifesaving treatment of lipophilic drug intoxications.
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